CRYOcheck Clot C is a clot-based assay presented in a frozen format intended for the quantitative determination of protein C activity in citrated human plasma. cryocheck Clot C functions by direct activation of protein C in the patient sample using a protein C activator. The common pathway of coagulation is initiated with Russell's viper venom (RVV-X) reagent to convert factor X to Xa, bypassing all factors above the common pathway.

• Frozen format eliminates reconstitution errors
• Unaffected by factor VIII:C activity levels up to 600%
• Unaffected by samples from patients heterozygous for the factor V_Leiden mutation
• Interference by lupus anticoagulants has not been observed
• Up to 300 tests per kit when using 3.0 mL format

CRYOcheck Clot C must be used with C & S Diluent, available separately from Precision BioLogic.